| 全身性感染与Toll样受体2、4相关性研究进展 |
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| 引用本文： | 张杰,万献尧.全身性感染与Toll样受体2、4相关性研究进展[J].医学与哲学,2009(11):50-53. |
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| 作者姓名： | 张杰 万献尧 |
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| 作者单位： | 大连医科大学附属一院重症医学科,辽宁大连116021 |
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| 摘 要： | 全身性感染是由感染所致的临床综合征，Toll样受体（TLR）导致的体内信号传导，使炎症反应级联放大，以及诱发机体免疫功能紊乱，致使机体对病原体清除效率降低。因此，阻断TLR传导通路可能会抑制全身性感染发生和发展的进程。
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| 关 键 词： | 全身性感染，Toll样受体2，Toll样受体4，免疫耐受 |
The New Progress of Study on Toll Like Receptor 2,4 in Correlation with Sepsis |
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| ZHANG Jie,WAN Xian-yao.The New Progress of Study on Toll Like Receptor 2,4 in Correlation with Sepsis[J].Medicine & Philosophy:Humanistic & Social Medicine Edition,2009(11):50-53. |
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| Authors: | ZHANG Jie WAN Xian-yao |
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| Institution: | .(The First Hospital Affiliated Dalian Medical University,Dalian 116021,China) |
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| Abstract: | Sepsis is a clinical syndrome, which is induced by infection. The signal transduction of TLR makes inflammatory reaction cascade amplification. In addition, TLR may make resistance mechanism disordering, diminish the efficiency of pathogen clearance. Therefore, it could be an effective method that block the signal transduction of TLR to hamper the process of sepsis. |
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| Keywords: | sepsis，TLR2，TLR4，immunologic tolerance |
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