Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders |
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| Authors: | Steven Paul Woods David J Moore Erica Weber Igor Grant |
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| Institution: | (1) Department of Psychiatry (0847), School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA;(2) HIV Neurobehavioral Research Center, Department of Psychiatry (0847), University of California, San Diego, 150 West Washington Street, 2nd floor, San Diego, CA 92103, USA |
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| Abstract: | Advances in the treatment of the human immunodeficiency virus (HIV) have dramatically improved survival rates over the past
10 years, but HIV-associated neurocognitive disorders (HAND) remain highly prevalent and continue to represent a significant
public health problem. This review provides an update on the nature, extent, and diagnosis of HAND. Particular emphasis is
placed on critically evaluating research within the realm of cognitive neuropsychology that aims to elucidate the component
processes of HAND across the domains of executive functions, motor skills, speeded information processing, episodic memory,
attention/working memory, language, and visuoperception. In addition to clarifying the cognitive mechanisms of HAND (e.g.,
impaired cognitive control), the cognitive neuropsychology approach may enhance the ecological validity of neuroAIDS research
and inform the development of much needed novel, targeted cognitive and behavioral therapies.
The research described was supported by MH73419 and MH62512 from the National Institutes of Health. The views expressed in
this article are those of the authors and do not reflect the official policy or position of the Department of the Navy, Department
of Defense, nor the United States Government. |
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| Keywords: | Human immunodeficiency virus AIDS dementia complex Neuropsychological assessment Cognitive science Cognitive impairment |
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