选择性颞叶梗塞对鼠学习记忆能力影响的定量研究

应用光化学的方法选择性诱导颞叶梗塞，同时测定学习记忆能力、神经功能缺失及梗塞面积。结果表明：颞叶梗塞鼠的学习记忆能力显著受损，但无明显感觉运动障碍；颞叶梗塞鼠的学习记忆受损程度与梗塞面积大小有关。结果提示选择性颞叶梗塞是一种理想的痴呆动物模型。

QUANTITATIVE STUDIES FOR EFFECT OF TEMPORAL INFARCT ON LEARNING AND MEMORY IN WISTAR RATS

The selective temporal infarct animal model induced photochemically was developed,It was determined in terms of learning and memory ability,neurological functional score and size of infarct area coincidentally for quantitative study of the learning and memory disorders in Wistar rats with temporal infarct,The results demonstrated that the learning and memory ability of rats with temporal infarct was damaged significantiy,while no sensory and motor dysfunctions were found..It also showed that the extents of learning and memory ability damage were related to the size of the te mporal infarct area.It is suggested that the selected temporal infarct is an ideal animal model of dementia.