The long-term effects of naloxone,dibutyryl cyclic CMP,and chlorpromazine on aggression in mice monitored by an automated device

A device that records the squeaks of attacked mice, used in combination with a microcomputer, was evaluated as a means of monitoring fighting over extended periods. The influences of chlorpromazine, naloxone, and dibutyryl cyclic cytidine 3′5′ monophosphate were monitored for 23 hours. These drugs differed in their ability to decrease squeaking over this extended period. Naloxone, although it significantly decreased squeaking in the short-term, did not influence the 23-hour total. In contrast, dibutyryl cyclic cytidine 3′,5′ monophosphate proved to have a potent influence that resulted in a significant decrease in the total squeaking recorded over 23 hours.