| 探讨人乳头瘤病毒L1蛋白功能及其临床意义 |
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| 引用本文： | 时艳梅,叶红,肖长义. 探讨人乳头瘤病毒L1蛋白功能及其临床意义[J]. 医学与哲学(人文社会医学版), 2009, 0(5): 46-47 |
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| 作者姓名： | 时艳梅 叶红 肖长义 |
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| 作者单位： | [1]三峡大学第一临床医学院,湖北宜昌443003 [2]三峡大学医学院,湖北宜昌443002 |
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| 基金项目： | 湖北省教育厅重大课题,项目编号：Z200713002;湖北省卫生厅科研基金,项目编号：JX3832;国家自然科学基金面上项目,项目编号：307770104 |
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| 摘 要： | 高危型别人乳头瘤病毒（HPV）感染在宫颈癌发生发展中具有重要作用。由于HPV L1蛋白结构特征及其精确的抗原特性，在粘附宿主细胞、识别病毒受体、协助病毒DNA的入胞转运中均发挥重要作用。检测患者宫颈损伤组织中L1蛋白的表达将有助于对患者是否具有传染性进行评估。本文将深刻思考HPV L1功能及其在感染机体并引发癌变的机制，以期更好的解读宫颈癌发病原理并最终应用于，强床治疗。
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| 关 键 词： | 乳头瘤病毒 衣壳蛋白 细胞分化 宫颈癌 |
Research of the Function of HPV L1 and Its Clinical Significance |
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| SHI Yan-mei,YE Hong,XIAO Chang-yi. Research of the Function of HPV L1 and Its Clinical Significance[J]. Medicine & Philosophy:Humanistic & Social Medicine Edition, 2009, 0(5): 46-47 |
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| Authors: | SHI Yan-mei YE Hong XIAO Chang-yi |
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| Affiliation: | (The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China) |
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| Abstract: | High risk human papillomavirus （HPV） infection is closely associated with development of cervical cancer. Owing to itsstructural feature and its antigenic specificity, HPV L1 plays an important role in recognizing host cell,adhering virus receptor and trafficking DNA to cellular nucleus, detecting the expression of Lt in cervical tissues will help for the evaluation of patients infectivity. This article thinks the function of HPV L1 and the mechanism of cervical carcinoma which caused by HPV, aiming to understand the etiopathogenisis and applied for clinical treatment. |
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| Keywords: | human papillomavirus L1 capsid protein cell differentiation cervical cancer |
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