On the nonassociative nature of working memory |
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| Institution: | 1. State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China;1. National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine; Shaanxi Province Center for Regenerative Medicine and Surgery Engineering Research; Shaanxi Provincial Key Laboratory of Magnetic Medicine; First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China;2. Institute of Regenerative and Reconstructive Medicine, Med-X Institute, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China;3. School of Future Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China;4. Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi’an, Shaanxi 710069, China;5. Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an 710127, China;1. Hospital Clínico Universitario Virgen de la Arrixaca, Ctra. Madrid-Cartagena, s/n, Murcia, Spain;2. Universidad de Murcia, Murcia, Spain |
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| Abstract: | Rats were trained in an eight-arm radial maze in two experiments. A “fixed set” of four arms, randomly selected and sequenced, was assigned to each rat. The fixed set was always presented in the same order. Each training trial began with rewarded forced choices of the four arms in the fixed set. The trial concluded with a free-choice test among all eight arms after a delay of about 40 min; choices of the four arms not in the fixed set were rewarded. The degree to which the identities and order of the arms in the fixed set had been learned was assessed in a reversal test. The four arms that were not in the fixed set were presented at the beginning of the reversal test trial; after the usual delay a free-choice test was given, but choices of arms in the fixed set were rewarded. In both experiments, the rats showed no negative transfer in the reversal test. Moreover, sequences of postdelay choices during training varied across days, and the sequence of choices during the reversal test did not match the sequence of arms in the fixed set. The rats therefore learned little if anything about the identities and the order of arms in the fixed set in spite of the consistencies between trials and the maintenance of the fixed set in memory for 40 min within trials. The finding is congruent with the view of working memory as nonassociative. |
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