Regulation of hypothalamic-pituitary-adrenal activity in response to cognitive therapy in patients with generalized anxiety disorder |
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Authors: | Email author" target="_blank">Gustavo?E?TafetEmail author Diego?J?Feder Denise?P?Abulafia Silvia?S?Roffman |
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Institution: | (1) Department of Psychiatry, Ilsan-Paik Hospital, Inje University, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, 411-706, Republic of Korea;(2) Clinical Emotion and Cognition Research Laboratory, 2240 Daehwa-dong, Ilsanseo-gu, Goyang, 411-706, Republic of Korea;(3) Department of Biomedical Engineering, Yonsei University, Wonju, Republic of Korea;(4) Graduate Program in Cognitive Science, Yonsei University, Seoul, Republic of Korea; |
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Abstract: | The aim of this study was to evaluate the efficacy of cognitive therapy (CT) in the treatment of generalized anxiety disorder
(GAD), as it would be reflected through both psychological and psychoneuroendocrinological parameters. For this purpose, a
group of outpatients with GAD were treated with CT for up to a maximum of 24 sessions. In order to assess psychological and
biological changes, anxiety-related symptoms were evaluated according to the Hamilton Anxiety Rating Scale (HAM-A), and the
hypothalamic-pituitary-adrenal (HPA) function was determined through assessment of circulating cortisol levels. A significant
decrease in the HAM-A scores, along with significant changes in plasma cortisol levels, were observed after completion of
treatment with CT. These observations contribute to demonstrate that the effect of certain psychotherapeutic approaches, such
as CT, may be observed at both psychological and biological levels. |
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Keywords: | |
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