Functional imaging of working memory and peripheral endothelial function in middle-aged adults |
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Authors: | Mitzi M. Gonzales Takashi Tarumi Hirofumi Tanaka Jun Sugawara Tali Swann-Sternberg Katayoon Goudarzi Andreana P. Haley |
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Affiliation: | 1. Department of Psychology, The University of Texas at Austin, Austin, TX, United States;2. Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX, United States;3. University of Texas Imaging Research Center, Austin, TX, United States |
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Abstract: | The current study examined the relationship between a prognostic indicator of vascular health, flow-mediated dilation (FMD), and working memory-related brain activation in healthy middle-aged adults. Forty-two participants underwent functional magnetic resonance imaging while completing a 2-Back working memory task. Brachial artery endothelial-dependent flow-mediated dilation (FMD) was assessed using B-mode ultrasound. The relationship between FMD and task-related brain activation in a priori regions of interest was modeled using hierarchical linear regression. Brachial FMD, was significantly related to reduced working memory-related activation in the right superior parietal lobule (β = 0.338, p = 0.027), independent of age, sex, systolic blood pressure, and full scale IQ (F(5, 36) = 2.66, p = 0.038). These data provide preliminary support for the association between a preclinical marker of endothelial dysfunction and cerebral hemodynamic alterations in healthy middle-aged adults. Considering the modifiable nature of endothelial function, additional investigations on the prognostic significance of FMD on future cognitive impairment are warranted. |
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Keywords: | Working memory Magnetic resonance imaging Cardiovascular disease Endothelium Middle-aged Cognition |
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