White matter integrity and pictorial reasoning in high-functioning children with autism |
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| Authors: | Chérif P Sahyoun John W Belliveau Maria Mody |
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| Institution: | MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States |
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| Abstract: | The current study investigated the neurobiological role of white matter in visuospatial versus linguistic processing abilities in autism using diffusion tensor imaging. We examined differences in white matter integrity between high-functioning children with autism (HFA) and typically developing controls (CTRL), in relation to the groups’ response times (RT) on a pictorial reasoning task under three conditions: visuospatial, V, semantic, S, and V + S, a hybrid condition allowing language use to facilitate visuospatial transformations. |
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| Keywords: | High-functioning autism Pictorial reasoning Language White matter |
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