Horizontal and vertical attentional orienting in Parkinson’s disease |
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Authors: | Gudrun MS Nys Patrick Santens Guy Vingerhoets |
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Institution: | 1. Laboratory for Neuropsychology, Department of Neurology, Ghent University, De Pintelaan 185 (4K3) 9000 Gent, Belgium;2. Department of Neurology, Ghent University Hospital, De Pintelaan 185 (1K12) 9000 Gent, Belgium |
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Abstract: | Patients with Parkinson’s disease (PD) typically suffer from an asymmetric degeneration of dopaminergic cells in the substantia nigra, resulting in right-sided (RPD) or left-sided (LPD) predominance of motor symptomatology. As the dopaminergic system is also involved in attention, we examined horizontal and vertical orienting of attention in LPD (N = 10), RPD (N = 9) and controls (N = 10). Four LPD patients demonstrated left neglect and three LPD patients demonstrated neglect for the upper visual field. LPD patients demonstrated a slower performance in detecting targets in the left hemifield and did not demonstrate a validity effect, unlike RPD patients and controls. RPD patients performed similar to controls, with the exception of one patient showing left and another showing right neglect, and two RPD patients demonstrated lower neglect. In sum, horizontal and vertical orienting of attention can be affected in Parkinson’s disease – particularly in LPD – from very subtle slowing to clinically detectable horizontal and/or vertical neglect. |
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Keywords: | Neglect Parkinson&rsquo s disease Attention Posner Asymmetry Disengagement Dopaminergic Cognitive |
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