The effects of selective ibotenate lesions of the hippocampus on conditioned inhibition and extinction |
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Authors: | Email author" target="_blank">K?H?ChanEmail author L?E?Jarrard T?L?Davidson |
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Institution: | (1) Department of Psychology and Neuroscience, Duke University, Durham, NC 27708, USA; |
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Abstract: | Previously, Solomon (1977) reported that aspiration lesions of the dorsal hippocampus in rabbits had no effect either on the
acquisition of Pavlovian conditioned inhibition or on performance during a subsequent retardation test. The present experiment
confirmed and extended these findings by showing that rats with ibotenate lesions of the complete hippocampus (the dorsal
and ventral hippocampus and the dentate gyrus) were also unimpaired on the same types of tasks. Additional tests with the
same rats showed that removing the hippocampus significantly impaired extinction of responding to a stimulus that had been
previously trained with an appetitive unconditioned stimulus. The performance of the lesioned rats on a summation test was
also marginally, but not significantly, different from that of controls. The data are discussed with reference to the idea
that the hippocampus is involved with the formation of some, but not all, types of inhibitory associations. |
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Keywords: | |
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