A review of dehydroepiandrosterone (DHEA) |
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Authors: | C. Norman Shealy M.D. Ph.D. |
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Affiliation: | 1. The Shealy Institute, 1328 East Evergreen, 65803, Springfield, MO
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Abstract: | Dehydroepiandrosterone (DHEA) is quantitatively the most abundant hormone in humans and mammals, with a wide variety of physiological effects, including major regulatory effects upon the immune system. Two of the most striking aspects of DHEA are a steady decline in DHEA with age and a significant deficiency in DHEA in patients with several major diseases, including cancer, atherosclerosis, and Alzheimer’s disease. The hormone is secreted in a non-sulfated (DHEA) and sulfated form (DHEA-S). The two are apparently interchangeable, and it appears likely that its physiological effects are achieved by derivative molecules that have yet to be identified. |
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