Neural functional organization of hallucinations in schizophrenia: Multisensory dissolution of pathological emergence in consciousness |
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| Authors: | Renaud Jardri Delphine Pins Maxime Bubrovszky Bernard Lucas Vianney Lethuc Christine Delmaire Vincent Vantyghem Pascal Despretz Pierre Thomas |
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| Institution: | 1. Centre Hospitalier Universitaire de Lille (CHRU), Lille, France;2. INSERM UMR-S1144, VariaPsy équipe 1, Hôpital Fernand Widal, APHP, Paris, France;3. APHP, Henri Mondor Hospitals, INSERM U955, Team 15 ''Psychiatry & Genetics'', Créteil, France;4. Neurospin, Uniact lab, CEA Saclay, France;5. Université Lille Nord de France, France;6. Université Droit & Santé Lille, SCA-Lab., PSYchiC team, Lille, France;7. UMC Utrecht, Utrecht, The Netherlands;8. BCN Neuroimaging Center (NIC), UMC Groningen, University of Groningen, The Netherlands;9. MRC Centre for Neuropsychiatric Genetics & Genomics, Cardiff University, Cardiff, UK;1. Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany;2. Brain Center for Motor and Social Cognition, Italian Institute of Technology, Parma, Italy;3. Department of Psychiatry and Psychotherapy III, Ulm University, Germany;4. Central Institute of Mental Health, Department of Addictive Behavior and Addiction Medicine, Mannheim, Germany;5. Department of Psychiatry and Psychotherapy II,Ulm University, Germany |
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| Abstract: | Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information from different modalities is strongly functionally connected to higher-order integrative areas. |
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| Keywords: | Multisensory Hallucinations Schizophrenia Functional MRI Diffusion tensor imaging Cortical thickness sLORETA EEG Repetitive trans-cranial magnetic stimulation |
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