| 磁共振动态增强扫描(DCE-MRI)与动脉粥样硬化斑块内新生微血管相关性实验研究 |
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| 引用本文： | 曲晓峰,杨海山,刘亚洁,刘书峰,李笋. 磁共振动态增强扫描(DCE-MRI)与动脉粥样硬化斑块内新生微血管相关性实验研究[J]. 医学与哲学(人文社会医学版), 2010, 0(2): 45-46,57 |
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| 作者姓名： | 曲晓峰 杨海山 刘亚洁 刘书峰 李笋 |
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| 作者单位： | [1]吉林大学中日联谊医院放射科,吉林长春130021 [2]大连医科大学附属第二医院放射科,辽宁大连116027 [3]大连市辽渔医院放射科,辽宁大连116113 |
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| 摘 要： | 通过动物实验探讨磁共振动态增强扫描成像参数S及SI%与动脉粥样硬化斑块内新生微血管的相关性。磁共振动态增强扫描参数S及SI%与新生微血管内皮细胞计数具有相关性(R=0.479,P0.01;R=0.433,P0.05),通过测定参数S及SI%对动脉粥样硬化斑块内新生微血管进行半定量测定,评价动脉硬化斑块易损性,为临床早期干预及治疗动脉硬化斑块提供可靠的影像学依据。
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| 关 键 词： | 磁共振动态增强扫描 动脉粥样硬化斑块 新生微血管 相关性 |
Correlative Experiment Study Of Dynamic Contrast Enhanced MR Imaging and Neovascularization In Atherosclerotic Plaques of Rabbits |
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| Affiliation: | QU Xiao- feng ,YANG Hai-shan ,LIU Ya-jie ,et al. (China--japan Union Hospital of Jilin University Radiology Department ,Changchun 130021 ,China) |
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| Abstract: | To discuss correlation of dynamic contrast enhanced MR imaging and neovascularization in atherosclerotic plaques of rabbits. To evaluate the fist phase rate of slope （S） and max rate of enhancement （SI%） and using immnohistochernical staining technique to observe endothelial cell in Neovascularization in atherosclerotic plaques（CD31 ）. Results indicate that dynamic contrast enhanced MR imaging parameter（S and SI%） correlated positively with neovascularization in atherosclerotic plaques. （R=0. 479, P〈0.01 R= 0. 433,P 〈0.05 ）. In Conclusion, to evaluate semi--quantitatively evaluation of neovascularization in atherosclerotic plaques by evaluating the fist phase rate of slope （S） and maximal rate of enhancement （ SI%）, estimate vulnerability of atherosclerotic plaques. To provide imaging evidence for the clinical and prevent heart cerebral vascular accident. |
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| Keywords: | dynamic contrast enhanced MR imaging（DCE--MRI） atherosclerotic plaques neovascularization correlation |
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