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An immunochemical approach to model and long-term suppression of depressive and anxiety behavior
Authors:Ashmarin Igor P  Danilova Raisa A  Rud'ko Olga I  Belopolskaya Maria V  Obukhova Maria F  Shmalgausen Elena V
Affiliation:Dept. of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow 119922, Russia. ashmarin25@mail.ru
Abstract:The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.
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