The Role of Optimism/Pessimism in HRQOL in Chronic Hepatitis C Patients

One hundred and twenty three outpatients with compensated chronic hepatitis C (CHC) completed the SF-36, BSI, and questions regarding the expected impact of CHC on their health. Respondents were categorized as optimists (N = 17, 13.8%), realists (N = 98, 79.6%), and pessimists (N = 8, 6.5%). Pessimism was associated with lower scores on nearly all SF-36 subscales (p < .001 –.03) and higher scores on 6 BSI subscales indicative of greater emotional distress (p < .05). Pessimism was not associated with demographics, liver disease severity, substance abuse, or comorbid medical conditions. However, pessimism was associated with the presence of a psychiatric comorbidity and self-reported health status (p < .05). We conclude that optimism/pessimism may be an important determinant of QOL and emotional status in CHC patients and that additional studies of cognitive predispositions and coping skills in CHC patients are warranted.