金属蛋白酶-9（MMP-9）及其组织抑制物-1（TIMP-1）在胰腺癌中的表达

探讨MMP-9和TIMP—1在胰腺癌癌细胞及间质的表达与胰腺癌分化程度、分期之间的关系。采用免疫组织化学方法，检测MMP-9和TIMP—1在胰腺癌细胞及间质细胞的表达。MMP-9在胰腺癌细胞和间质组织中均有表达。TIMP—1主要表达在胰腺癌细胞中。MMP-9在胰腺癌间质细胞中的表达高于胰腺癌癌旁组织间质细胞，与胰腺癌的病理分级、分期呈正相关。结论认为MMP-9在胰腺癌间质细胞的表达可能参与胰腺癌的浸润和转移，对预后判断、诊断及治疗具有一定的意义。

Expressions of Matrix Metalloproteinase 9 and its Tissue Inhibitor 1 in Pancreatic Carcinoma

To investigate the expression of MMP-9 and TIMP-1 in pancreatic carcinoma tissues and the relations between different--derived expression and the differentiation, stage. We use immunohistoehemistry analyzed the MMP-9 , TIMP -1 expression in tissues from resected pancreatic carcinoma. MMP-9 was detected in both pancreatic cancer cells and stroma. TIMP-1 was expressed predominantly in pancreatic cancer cells. MMP-9 expression in stroma was positively correlated with grade and staging. The expression of MMP-9 is correlated with the invasion and metastasis of pancreatic cancer, which is of significance to prognosis, diagnosis and treatment.