|
|||||
|
|
Family Communication of BRCA1/2 Results and Family Uptake of BRCA1/2 Testing in a Diverse Population of BRCA1/2 Carriers |
|
| Authors: | Julia Fehniger Feng Lin Mary S. Beattie Galen Joseph Celia Kaplan |
| Affiliation: | 1. Cancer Risk Program, University of California, San Francisco, San Francisco, CA, USA 2. University of Michigan Medical School, Ann Arbor, MI, USA 3. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA 4. Department of Anthropology, History, and Social Medicine, University of California, San Francisco, San Francisco, CA, USA 5. Department of Medicine, University of California, San Francisco, San Francisco, CA, USA 6. University of California, San Francisco, 3333 California Street, Box 0856, San Francisco, CA, 94143, USA |
| Abstract: | Previous studies examining communication of BRCA1/2 results with relatives and family uptake of BRCA1/2 testing have sampled from predominantly white, high SES cohorts ascertained solely from tertiary care centers. No studies have focused on family communication and testing among relatives of diverse BRCA1/2 carriers. We conducted structured interviews with 73 BRCA1/2 carriers identified at a public hospital and a tertiary cancer center. We asked participants if each first- and second-degree relative was aware of their BRCA1/2 results and whether or not each relative had tested. Generalized estimating equations identified rates and predictors of family communication and testing. Participants disclosed their test results to 73 % of 606 eligible relatives and 31 % of 514 eligible relatives tested. Communication and testing rates were similar for relatives of participants from the public hospital and the tertiary cancer center. Hospital site was not a significant predictor of either result disclosure or relative uptake of testing. African American and Asian/Pacific Islander participants were significantly less likely to disclose their results to their relatives; relatives of African American participants were significantly less likely to test. Addressing these disparities will require further research into the best ways to facilitate family communication and counsel at-risk relatives of racially and socioeconomically diverse BRCA1/2 mutation carriers. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |