The associations of the Five Factor Model of personality with inflammatory biomarkers: A four-year prospective study

This study evaluated the associations of the Five Factor Model of personality with two inflammation biomarkers, C-reactive protein and fibrinogen, and the possible moderating effects of common health-related behaviors (physical activity and smoking) concurrently and over four years, while adjusting for socio-demographic and health status. Participants were individuals who underwent a health examination at two points of time, T1 (n = 1709) and T2 (n = 923), about four years apart. Regression analyses uncovered positive associations between Neuroticism and Extraversion with two inflammatory biomarkers at baseline (T1) and over time (T2) and increases in their levels over time. Additionally, a synergistic interaction of neuroticism and physical inactivity was associated with higher levels of inflammation biomarkers at both time periods. Openness was negatively associated with inflammation biomarkers at T1 and T2, but not with changes in their levels. No significant associations were found for Agreeableness and Conscientiousness. The results suggest that personality traits might be involved in the inflammatory process both concurrently and over time, and thus indicate a possible mechanism by which personality traits might influence health, especially cardiovascular disease risk.