| 2型糖尿病与骨代谢标志物相关性分析 |
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| 引用本文： | 王小曼,;蒋孝东,;王志芳,;张洁蕾,;赵花,;郑丽丽. 2型糖尿病与骨代谢标志物相关性分析[J]. 医学与哲学(人文社会医学版), 2014, 0(8): 50-52 |
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| 作者姓名： | 王小曼, 蒋孝东, 王志芳, 张洁蕾, 赵花, 郑丽丽 |
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| 作者单位： | [1]郑州大学第一附属医院内分泌科,河南郑州450052; [2]郑州市卫生学校,河南郑州450005 |
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| 摘 要： | 探讨骨代谢标志物与2型糖尿病的相关性。收集2型糖尿病患者50例为糖尿病（T2DM ）组，非糖尿病患者17例为对照组，检测所有研究对象的血清骨代谢标志物、空腹血糖（FBG）、糖化血红蛋白（HbA1c）。与对照组相比，T2DM 组血清25-羟维生素D3（25-OH VitD3）、骨钙素（BGP）、总Ⅰ型胶原氨基端延长肽（TPINP）水平明显下降，β胶原特殊序列（β-CTx）水平升高；血清25-OH VitD3与 HbA1c呈负相关，BGP与 FBG呈负相关，TPINP与 FBG和 HbA1c呈负相关，β-CTx与FBG、HbA1c呈正相关。提示2型糖尿病与骨代谢标志物存在一定的相关性。
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| 关 键 词： | 2型糖尿病 骨质疏松 骨代谢 |
Correlation Analysis of Bone Metabolism Markers with Type 2 Diabetes Mellitus |
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| Affiliation: | WANG Xiao-man, JIANG Xiao-dong, WANG Zhi- fang , et aL. (Department of Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China) |
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| Abstract: | To explore the correlation of bone metabolism markers with type 2 diabetes mellitus （T2DM ） .Fifty patients with T2DM were recruited in T2DM group ,while seventeen non-diabetic patients were recruited in control group .Bone metabolism markers ,fasting blood-glucose （FBG） and HbA1c of all objects were detected .Compared with control group , the levels of 25-OH VitD3 ,BGP ,TPINP in patients of T2DM group were significantly decreased ,while the level of β-CTx was significantly elevated .25-OH VitD3 was negatively correlated with HbA1c ,BGP was negatively correlated with FBG , and TPINP was negatively correlated with FBG and HbA1c .β-CTx was positively correlated with FBG and HbA1c .That suggests bone metabolism markers is correlated with T 2DM . |
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| Keywords: | type 2 diabetes mellitus osteoporosis bone metabolism |
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