降钙素原、内毒素检测在新生儿败血症早期诊断的临床研究

为了探讨降钙素原（PCT ）及内毒素在新生儿败血症早期诊断中的临床价值，本研究选择在我院新生儿科收治的新生儿败血症患儿60例作为研究组，另选同期住院的非感染性疾病患儿40例作为对照组，测定两组新生儿血清 PCT 和内毒素含量，比较两个指标诊断新生儿败血症的敏感性和特异性。结果显示研究组败血症新生儿 PCT 和内毒素的含量均比对照组升高明显，差异有统计学意义（P＜0．05），PCT 的敏感性及特异性分别为90．78％、92．82％；内毒素的敏感性及特异性分别为86．73％、62．6％。提示 PCT 和内毒素在新生儿败血症早期诊断中的敏感性和特异性高，可作为临床诊断和治疗效果评价的重要指标。

Clinical Study on the Early Diagnosis of Neonatal Septicemia by Procalcitonin and Endotoxin Determination

To investigate the clinical effect of procalcitonin （PCT ） and endotoxin determination on early diagnosis in neonatal septicemia ,60 cases of neonatal septicemia in our hospital were selected as research group ,while 40 cases of neonates with non-infectious disease were chosen as control group . The contents of serum PCT and endotoxin in two groups were detected ,and the sensibility and specificity of two indexes for diagnosis in neonatal septicemia was analyzed . The results showed that the content of PCT and endotoxin in septicemia group were significantly higher than those in control group ,and there was statistical deference （P ＆lt; 0 .05） .The sensibility and specificity of PCT was 90 .78% and 92 .82% while those for endotoxin were 86 .73% and 62 .6% ,respectively .This study indicates that the sensibility and specificity of PCT and endotoxin is high for early diagnosis in neonatal septicemia ,and they are important indexes of evaluation in clinical diagnosis and treated effect .