紫杉醇、顺铂在中晚期宫颈癌同步放化疗中的临床疗效比较

探讨61例中晚期宫颈癌患者分别行紫杉醇、顺铂同步放化疗的疗效和不良反应。两组近期有效率，1年、2年、3年总生存率，无瘤生存率差异无统计学意义（P＞0．05）。紫杉醇同步放化疗组主要表现为白细胞计数下降、神经毒性和心脏毒性；顺铂同步放化疗组主要表现为消化道反应和肝肾功能受损；两组的消化道反应、神经毒性、肝肾功能受损发生率差异有统计学意义（P＜0．05），紫杉醇组骨髓抑制、心脏毒性发生率均高于顺铂组，但差异无统计学意义（P ＞0．05）。顺铂组肝功能受损发生率稍高于紫杉醇组，但差异无统计学意义（P＞0．05）。同步放化疗中使用紫杉醇治疗中晚期宫颈癌疗效与顺铂相当，不良反应可耐受。

Comparison of the Effect of Paclitaxel and Cisplatin in the Concurrent Chemoradiotherapy of Cervical Cancer

To compare the efficacy and side effects of paclitaxel ,61 cases of patients with advanced cervical cancer were performed cisplatin chemoradiotherapy .Two groups of recent efficiency ,1 year ,2 years ,3 years overall survival rate , tumor free survival rates were not statistically significant （ P ＆lt; 0 .05） . Paclitaxel concurrent chemoradiotherapy group mainly manifested decreased white blood cell count ,neurotoxicity ,cardiac toxicity Cisplatin chemoradiotherapy group mainly caused digestive tract reaction and damage to liver and kidney function .The difference of gastrointestinal reaction , liver and kidney function damage incidence of neurotoxicity was statistically significant （P＆lt; 0 .05） ,paclitaxel group bone marrow suppression ,the occurrence of cardiac toxicity was higher than that of cisplatin group ,but the difference was not statistically significant （P＆lt; 0 .05） .The incidence of liver function damage of the cisplatin group was slightly higher than that of paclitaxel group ,but the difference was not statistically significant （P ＆lt; 0 .05） .Concurrent chemotherapy in the treatment of advanced cervical cancer with paclitaxel and cisplatin is equivalent in efficacy and the adverse reactions , adverse reactions can be tolerated .