Differential effects of cannabinoid receptor agonist on social discrimination and contextual fear in amygdala and hippocampus |
| |
Authors: | Segev Amir Akirav Irit |
| |
Affiliation: | Department of Psychology, University of Haifa, Haifa 31905, Israel. |
| |
Abstract: | We examined whether the cannabinoid receptor agonist WIN55,212-2 (WIN; 5 μg/side) microinjected into the hippocampus or the amygdala would differentially affect memory processes in a neutral vs. an aversive task. In the aversive contextual fear task, WIN into the basolateral amygdala impaired fear acquisition/consolidation, but not retrieval. In the ventral subiculum (vSub), WIN impaired fear retrieval. In the neutral social discrimination task, WIN into the vSub impaired both acquisition/consolidation and retrieval, whereas in the medial amygdala WIN impaired acquisition. The results suggest that cannabinoid signaling differentially affects memory in a task-, region-, and memory stage-dependent manner. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|