Decline and Compensation in Aging Brain and Cognition: Promises and Constraints |
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Authors: | Naftali Raz |
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Institution: | (1) Institute of Gerontology and Department of Psychology, Wayne State University, Detroit, MI 48202, USA |
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Abstract: | Age-related cognitive declines are common and inevitable, but life trajectories of brain and cognitive functions are variable
and plastic. To identify the mechanisms of decline, the prospects for improvement, and the constraints on the remedial approaches,
the contributors of this special issuer examine several diverse areas of cognitive and brain aging: from structural and metabolic
brain aging to genetics, and from age-sensitive cognitive domains to those that resist aging. In spite of such thematic diversity,
several common threads are clear. To achieve better compensation for age-related changes in cognition, we need to understand
their brain substrates, telling cognitively relevant from epiphenomenal. We also need to understand the sources of profound
individual variability in aging trajectories, and to learn to tailor interventions to specific individual profiles of decline. |
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