味觉厌恶性条件反射与条件反射性免疫抑制的研究

以环磷酰胺的注射为非条件刺激（ＵＣＳ），糖精水的摄入为条件刺激（ＣＳ），并以血白细胞和淋巴细胞数量及脾淋巴细胞的转化反应为免疫指标，糖精水的饮用量为行为指标，通过改变条件刺激与非条件刺激结合的次数来观察条件反射性厌恶行为与条件反射性免疫抑制的反应。结果表明不管是一次性的还是两次性的ＣＳ－ＵＣＳ结合训练都能使动物明显地建立起味觉厌恶性条件反射，然而条件反射性免疫抑制只在两次性ＣＳ－ＵＣＳ结合训练后才

STUDY ON CONDITIONED IMMUNOSUPPRESSION AND CONDITIONED TASTE AVERSION

Cyclophosphamide (CY), an immunosuppressive agent, was used as an unconditioned stimulus (UCS) in a conditioned taste aversion (CTA) paradigm with saccharin as the conditioning stimulus (CS) in a two-bottle preference drinking procedure. Conditioned behavioral and immunological responses were observed under both one trial of CS-UCS paring and two trials of CS-UCS paring. Data showed that CTA occurred under both one trial and tWo trials of CS-UCS paring, but conditioned immunosuppression, as assessed by spleen cell proliferation to mitogen and the number of peripheral leukocyte and lymphocyte, required 2 parings. These results suggest that conditioned behavioral and immunological changes might occur independently.