Strain-dependent effects of post-training dopamine receptor agonists and antagonists on memory storage in mice. |
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Authors: | V Cestari C Castellano S Cabib S Puglisi-Allegra |
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Affiliation: | Istituto di Psicobiologia e Psicofarmacologia, C.N.R., Roma, Italy. |
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Abstract: | Post-training administration of the selective D1 or D2 agonists SKF 38393 and LY 171555 dose dependently impairs retention of an inhibitory avoidance response in DBA/2 mice. In agreement, the selective D1 or D2 antagonists SCH 23390 and (-)-sulpiride improve retention. These effects are opposite to those observed in the C57BL/6 strain, as previously reported. Moreover, B6D2F1 hybrids present a response to SKF 38393, LY 171555, SCH 23390, and (-)-sulpiride that parallels that of the C57BL/6 strain, thus suggesting that the neural mechanisms underlying the effects of DA agonists or antagonists on memory processes may be inherited through a dominant mode of inheritance. |
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