(1) Council for International Organizations of Medical Sciences (CIOMS), c/o World Health Organization, Avenue Appia, CH-1211 Geneva 27, Switzerland
Abstract:
Based on worldwide consultations with experts in science and ethics the revised CIOMS 2002 International Ethical Guidelines
for Biomedical Research Involving Human Subjects provide guidance on when the use of placebo as a comparator in clinical research
is ethically acceptable. The article reviews the main points of the CIOMS Guidelines and commentaries including the use of
placebo in situations where the best current method is available and the relation of placebo to established effective intervention.
It discusses the use of placebo in externally sponsored research in low-resource countries and requirements for informed consent
related to placebo studies.
An earlier version of this paper was presented at an international conference, “Placebo: Its Action and Place in Health Research
Today,” held in Warsaw, Poland on 12–13 April, 2003.