The role of the prefrontal cortex in the go/no-go task in humans: a positron emission tomography study

To study the localization of response inhibition in the human brain, especially the role of the prefrontal cortex and laterality of its activation, we used positron emission tomography (PET) to measure regional cerebral blood flow in 11 right-handed participants while they performed a go/no-go and a simple control reaction-time task. In the control task, the participants responded to a target stimulus following a cue stimulus. In the go/no-go task they were instructed to inhibit the required response if the target stimulus did not appear. These tasks were performed using each hand. The right prefrontal cortex was found to be significantly activated when the go/no-go task was compared with the control task, regardless of the responding hand. The results indicated that response inhibition per se may be controlled by the right prefrontal cortex regardless of response hand for right-handed participants.