TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia |
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| Authors: | Naeser Margaret A Martin Paula I Theoret Hugo Kobayashi Masahito Fregni Felipe Nicholas Marjorie Tormos Jose M Steven Megan S Baker Errol H Pascual-Leone Alvaro |
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| Affiliation: | aV.A. Boston Healthcare System, Harold Goodglass Boston University Aphasia Research Center, Boston University School of Medicine, USA;bBerenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA;cInstitut Guttmann, Barcelona, Spain;dCenter for Cognitive Neuroscience, Dartmouth College, Hanover, NH, USA |
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| Abstract: | This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. |
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| Keywords: | TMS Brain stimulation Aphasia Stroke rehabilitation |
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