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Transient beneficial effects of excitatory theta burst stimulation in a patient with phonological agraphia after left supramarginal gyrus infarction |
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| Authors: | Nardone Raffaele De Blasi Pierpaolo Zuccoli Giulio Tezzon Frediano Golaszewski Stefan Trinka Eugen |
| Institution: | a Department of Neurology, Christian Doppler Clinic, Paracelsus Medical University, Salzburg, Austria b Department of Neurology, Franz Tappeiner Hospital, Meran/o, Italy c Department of Economics, Collegio Carlo Alberto, University of Turin, Torino, Italy d Radiology Department, Children’s Hospital of Pittsburgh at the University of Pittsburgh Medical Center, USA |
| Abstract: | We report a patient showing isolated phonological agraphia after an ischemic stroke involving the left supramarginal gyrus (SMG). In this patient, we investigated the effects of focal repetitive transcranial magnetic stimulation (rTMS) given as theta burst stimulation (TBS) over the left SMG, corresponding to the Brodmann area (BA) 40. The patient and ten control subjects performed a dictational words and nonwords writing task before, and 5 and 30 min after they received excitatory intermittent TBS (iTBS) over the left BA 40, the right hemisphere homologous to BA 40, the Wernicke’s area, or the primary visual cortex.ITBS over the left SMG lead to a brief facilitation of phonological non-words writing to dictation. This case study report illustrates that rTMS is able to influence, among other language functions, the phonological loading processes during the written language production in stroke patients. |
| Keywords: | Phonological agraphia Stroke Supramarginal gyrus Transcranial magnetic stimulation Theta burst stimulation |
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