Dopamine regulation of human speech and bird song: a critical review |
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Authors: | Simonyan Kristina Horwitz Barry Jarvis Erich D |
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Affiliation: | a Departments of Neurology and Otolaryngology, Mount Sinai School of Medicine, New York, NY, United States b Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States c Howard Hughes Medical Institute, Department of Neurobiology, Duke University, Durham, NC, United States |
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Abstract: | To understand the neural basis of human speech control, extensive research has been done using a variety of methodologies in a range of experimental models. Nevertheless, several critical questions about learned vocal motor control still remain open. One of them is the mechanism(s) by which neurotransmitters, such as dopamine, modulate speech and song production. In this review, we bring together the two fields of investigations of dopamine action on voice control in humans and songbirds, who share similar behavioral and neural mechanisms for speech and song production. While human studies investigating the role of dopamine in speech control are limited to reports in neurological patients, research on dopaminergic modulation of bird song control has recently expanded our views on how this system might be organized. We discuss the parallels between bird song and human speech from the perspective of dopaminergic control as well as outline important differences between these species. |
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Keywords: | AFP, anterior forebrain pathway aDLM, anterior dorsolateral medial nucleus of the thalamus DIP, dorsointermedius posterior nucleus of the thalamus GABA, gamma-aminobutyric acid GPi, globus pallidus, internal segment GPe, globus pallidus, external segment HVC, nucleus of the nidopallium - letter-based name LMC, laryngeal motor cortex LMAN, lateral part of magnocellular nucleus of the anterior nidopallium MAN, magnocellular nucleus of the anterior nidopallium |
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