Activity and exploratory behavior after lesions of the medial entorhinal cortex in the woodmouse (Apodemus sylvaticus) |
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| Authors: | F Schenk F Inglin M Gyger |
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| Affiliation: | 1. Laboratory of Inflammation Pharmacology, Institute of Pharmacology and Morphophysiology, Faculty of Veterinary Science, Universidad Austral de Chile, Valdivia, Chile;2. Department of Pathology and Pathogen Biology, Royal Veterinary College, Hawkshead Lane, Hatfield AL9 7TA, UK;3. Institute of Parasitology, Justus Liebig University Giessen, Schubertstr. 81, BFS, 35392 Giessen, Germany;1. Agroforestry Department, University of Extremadura, Avda. Virgen del Puerto 2, 10600 Plasencia, Cáceres, Spain;2. Instituto de Investigación en Recursos Cinegéticos (IREC, CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13005 Ciudad Real, Spain;3. Louisiana State University, Museum of Natural Science, 119 Foster Hall, Baton Rouge, LA 70803, USA;4. Laboratorios Hipra S.A., La Selva, 135, 17170 Amer, Girona, Spain;5. Plaza del Mercado, 10, 17853 Tortella, Girona, Spain;1. Department of Pediatrics, Pediatric Rheumatology Research, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Clinical and Translational Research Center, 875 Ellicott St, Buffalo, NY 14203, USA;2. Department of Biomedical Engineering, University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Clinical and Translational Research Center, 875 Ellicott St, Buffalo, NY 14203, USA;3. Department of Pediatrics, Pulmonology Section, University at Buffalo, Women and Children''s Hospital of Buffalo, 239 Bryant St, Buffalo, NY 14203, USA;4. Department of Medicine, Section on Pulmonary, Critical Care, and Sleep Medicine, Buffalo General Medical Center Heart and Lung Center, 219 Bryant St./100 High St. B-8, Buffalo, NY 14222, USA |
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| Abstract: | The effects of bilateral electrolytic lesions of the entorhinal cortex were studied in male adult woodmice. Experiments were designed to allow separate analysis of the basal activity level and exploratory behavior. Activity recording was conducted in three situations: (a) 24-hr wheel running in the home cage pre- and postoperatively; (b) 24-hr activity composition in a large enclosure over 4 days, 5 to 9 days postoperatively; and (c) sequence and duration of visits in a residential plus maze 11 to 14 days postoperatively. Medial entorhinal cortex lesion involving the para- and presubiculum increased the 24-hr amount of movements in the enclosure (b) without increasing wheel running in any situation (a or b). This lesion also enhanced the locomotor reactivity to being introduced into the plus maze and impaired exploratory behavior. This last effect was equally apparent when the whole situation was new or when part of the familiar maze was modified. Lesioned woodmice did notice the new element but did not show active focalization of their behavior on that element. Data showed that lesion induced hyperactivity and changes of exploratory behavior were not necessarily associated. Novelty detection was performed but it is not clear now on what information this discrimination was based. |
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