Independent self-construal mediates the association between CYP19A1 gene variant and subjective well-being |
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| Affiliation: | 1. Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, SAR, China;2. Department of Psychiatry, Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;1. Hong Kong Baptist University, Hong Kong;2. BNU-HKBU United International College, China;3. Hong Kong University, Hong Kong;1. Department of Mathematics, City University of Hong Kong, Kowloon, Hong Kong, China;2. Department of Computer Science and Engineering, Southern University of Science and Technology, Shenzhen, China |
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| Abstract: | Testosterone and estrogen are involved in self-related behavioral dispositions and experiences of subjective well-being. In this study, we investigated to what extent the aromatase (CYP19A1) gene, which encodes an enzyme in converting testosterone into estrogen, contributes to subjective well-being and in another self-related disposition: independent and interdependent self-construal. In study 1, a meta-analysis showed that the GG genotype of CYP19A1 (a G/A substitution at Val80, rs700518) was associated with higher testosterone and lower estradiol. In study 2, an empirical study of individuals with the GG (n = 115), AG (n = 286) and AA (n = 193) genotypes indicated that individuals with the GG genotype exhibited higher independent self-construal and higher subjective well-being. The association between the GG genotype of CYP19A1 Val80 and subjective well-being was mediated by the independent self-construal. Our findings reinforce the idea that personality traits such as independent self-construal explain the link between genetic variant and subjective well-being. |
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| Keywords: | Self-construal Subjective well-being Aromatase Testosterone Estrogen |
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