Regional brain activity change predicts responsiveness to treatment for stuttering in adults |
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| Authors: | Roger J Ingham Yuedong Wang Janis C Ingham Anne K Bothe Scott T Grafton |
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| Institution: | 1. Department of Speech and Hearing Sciences, University of California, Santa Barbara, USA;2. Department of Statistics and Applied Probability, University of California, Santa Barbara, USA;3. Department of Psychological and Brain Sciences, University of California, Santa Barbara, USA;4. Department of Communication Sciences and Special Education, University of Georgia, USA |
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| Abstract: | Developmental stuttering is known to be associated with aberrant brain activity, but there is no evidence that this knowledge has benefited stuttering treatment. This study investigated whether brain activity could predict progress during stuttering treatment for 21 dextral adults who stutter (AWS). They received one of two treatment programs that included periodic H215O PET scanning (during oral reading, monologue, and eyes-closed rest conditions). All participants successfully completed an initial treatment phase and then entered a phase designed to transfer treatment gains; 9/21 failed to complete this latter phase. The 12 pass and 9 fail participants were similar on speech and neural system variables before treatment, and similar in speech performance after the initial phase of their treatment. At the end of the initial treatment phase, however, decreased activation within a single region, L. putamen, in all 3 scanning conditions was highly predictive of successful treatment progress. |
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| Keywords: | AUC area under the curve AWS adults who stutter CONT controls E establishment FDR false discovery rate FG fail group MONO monologue MPI modifying phonation intervals NAT speech naturalness PG pass group %SS percent syllables stuttered PS prolonged speech PT pretreatment READ oral reading REST eyes closed rest ROC receiver operating characteristics SFSPM stutter-free syllables spoken per minute T transfer TRPI target range phonated interval |
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