Latent Class Analysis of Antisocial Behavior: Interaction of Serotonin Transporter Genotype and Maltreatment |
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Authors: | James J Li Steve S Lee |
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Institution: | (1) Department of Psychology, University of California, Los Angeles (UCLA), 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, USA; |
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Abstract: | To improve understanding about genetic and environmental influences on antisocial behavior (ASB), we tested the association
of the 44-base pair polymorphism of the serotonin transporter gene (5-HTTLPR) and maltreatment using latent class analysis
in 2,488 boys and girls from Wave 1 of the National Longitudinal Study of Adolescent Health. In boys, ASB was defined by three
classes (Exclusive Covert, Mixed Covert and Overt, and No Problems) whereas in girls, ASB was defined by two classes (Exclusive
Covert, No Problems). In boys, 5-HTTLPR and maltreatment were not significantly related to ASB. However, in girls, maltreatment,
but not 5-HTTLPR, was significantly associated with ASB. A significant interaction between 5-HTTLPR and maltreatment was also
observed, where maltreated girls homozygous for the short allele were 12 times more likely to be classified in the Exclusive
Covert group than in the No Problems group. Structural differences in the latent structure of ASB at Wave 2 and Wave 3 prevented
repeat LCA modeling. However, using counts of ASB, 5-HTTLPR, maltreatment, and its interaction were unrelated to overt and
covert ASB at Wave 2 and only maltreatment was related to covert ASB at Wave 3. We discuss these findings within the context
of sex differences in ASB and relevant models of gene-environment interplay across developmental periods. |
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