| 石杉碱甲对应激诱导的吗啡行为敏感化表达的影响 |
| |
| 引用本文： | 张静,李新旺,马兰花. 石杉碱甲对应激诱导的吗啡行为敏感化表达的影响[J]. 心理学报, 2010, 42(3): 387-394. DOI: |
| |
| 作者姓名： | 张静 李新旺 马兰花 |
| |
| 作者单位： | (;1.首都师范大学心理学系, 北京市“学习与认知”重点实验室, 北京 100048) ;(;2.湛江师范学院基础教育学院科学教育系, 广东 524300) ; |
| |
| 基金项目： | 北京市教委科技发展计划项目(KM200710028021)的资助 |
| |
| 摘 要： | 为探讨石杉碱甲对应激诱导的吗啡行为敏感化表达的影响, 将40只动物随机分为5组: 盐水组、石杉碱甲组、吗啡组、应激组、石杉碱甲+应激组。实验发现, 急性/慢性空瓶应激都能够激发吗啡行为敏感化的表达, 而石杉碱甲能够显著抑制空瓶应激的这种激发作用。经过吗啡点燃后, 急性空瓶应激并不能显著影响动物的行为敏感化, 提示与成瘾性药物的再现相比, 空瓶应激对动物的影响力度较小。研究结果表明, 石杉碱甲能够抑制急性/慢性空瓶应激诱导的吗啡行为敏感化表达, 表明这类胆碱酯酶抑制剂有可能成为治疗药物依赖的潜在药物。
|
| 关 键 词： | 石杉碱甲 行为敏感化 吗啡 应激 |
| 收稿时间： | 2009-06-14 |
Effects of Huperzine A on Stress Induced Expression of Morphine Behavioral Sensitization |
| |
| ZHANG Jing,LI Xin-Wang,MA Lan-Hua. Effects of Huperzine A on Stress Induced Expression of Morphine Behavioral Sensitization[J]. Acta Psychologica Sinica, 2010, 42(3): 387-394. DOI: |
| |
| Authors: | ZHANG Jing LI Xin-Wang MA Lan-Hua |
| |
| Affiliation: | (;1. Beijing Key Laboratory of Learning and Cognition; Department of Psychology, Capital Normal University, Beijing 100048 China) ;(;2.Department of Science Education, Basic Education College of Zhanjiang Normal University, Guangdong 524300, China) ; |
| |
| Abstract: | Behavioral sensitization is defined as an increased behavioral response after repeated intermittent treatment with various drugs of abuse and is thought to be involved in drug abuse and addiction. This experiment examined the effects of Huperzine A on stress-induced expression of morphine behavioral sensitization in rats. Rats were treated with saline or morphine (3 mg/kg) for 7 days to induce behavioral sensitization (defined as a progressive increase of locomotor activity in the current study). In the sub... |
| |
| Keywords: | Huperzine A behavioral sensitization morphine stress |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《心理学报》浏览原始摘要信息 |
|
点击此处可从《心理学报》下载全文 |
|
