ROC in animals: Uncovering the neural substrates of recollection and familiarity in episodic recognition memory |
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| Authors: | Magdalena M. Sauvage |
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| Affiliation: | 1. Ruhr-Universität Bochum, Institut für Philosophie II - Carnap-Institut für Philosophie und Wissenschaft, Universitätsstraße 150, D-44780 Bochum;2. Department of Psychiatry, University of Köln, Kerpener Str. 62, 50924 Köln, Germany;1. Department of Psychology, University of California, Davis, CA 95616, United States;2. Center for Neuroscience, University of California, Davis, CA 95616, United States;3. Center for Mind and Brain, University of California, Davis, CA 95616, United States;1. Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany;2. Department of Neurology, Municipal Hospital Dortmund, Dortmund, Germany;1. Department of Pathology, University of Veterinary Medicine, Buenteweg 17, D-30559 Hannover, Germany;2. Center for Systems Neuroscience, Hannover, Germany;1. Department of Acute and Chronic Care, Johns Hopkins University School of Nursing, Baltimore, Maryland;2. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland;3. Department of Biobehavioral Health, The Pennsylvania State University, University Park, Pennsylvania |
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| Abstract: | It is a consensus that familiarity and recollection contribute to episodic recognition memory. However, it remains controversial whether familiarity and recollection are qualitatively distinct processes supported by different brain regions, or whether they reflect different strengths of the same process and share the same support. In this review, I discuss how adapting standard human recognition memory paradigms to rats, performing circumscribed brain lesions and using receiver operating characteristic (ROC) methods contributed to solve this controversy. First, I describe the validation of the animal ROC paradigms and report evidence that familiarity and recollection are distinct processes in intact rats. Second, I report results from rats with hippocampal dysfunction which confirm this finding and lead to the conclusion that the hippocampus supports recollection but not familiarity. Finally, I describe a recent study focusing on the medial entorhinal cortex (MEC) that investigates the contribution of areas upstream of the hippocampus to recollection and familiarity. |
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