Gallbladder distention and the effects of several drugs on heart rate,respiratory movements and cortical potentials in cats with hypothalamic lesions

The effects of chronic hypothalamic lesions and various drugs on the viscero-visceral reflexes of cats have been investigated, utilizing measurement of the bioelectrical activity of the cerebral cortex. After coagulation of the posterolateral hypothalamus the heart rate decreased by 40–60 beats per minute, but eventually it regained its initial value. The viscero-visceral reflexes from the gallbladder to the heart were preserved after the operative procedure. Chlorpromazine and atropine blocked both arousal and the cardiorespiratory response to stimulation of the gallbladder. Similar effects were produced by novocaine and pantocaine.