Contextualizing neuroticism in the Hierarchical Taxonomy of Psychopathology

Neuroticism is the personality trait most consistently and strongly connected to psychopathology. The majority of research on the relationship between traits and mental illness has focused on neuroticism’s connection with broad psychopathology spectra or discrete disorders. However, both personality and psychopathology are hierarchically-organized domains that may be examined at multiple levels of fidelity and bandwidth from very specific thoughts, feelings, and behaviors (i.e., nuance traits or symptoms) to very broad patterns indexing many interrelated tendencies (i.e., general factors). The Hierarchical Taxonomy of Psychopathology (HiTOP) is a recently proposed nosologic framework for psychopathology symptoms and domains that accounts for this tiered organization. Here, we illustrate how neuroticism-psychopathology relationships—both what is known and unknown—may be elucidated through the HiTOP system.