Occasion setting and drug tolerance |
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Authors: | Barbara M C Ramos Shepard Siegel José Lino O Bueno |
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Institution: | 1. Department of Psychology, McMaster University, L8S 4K1, Hamilton, Ontario, Canada 2. Psychobiology Program, University of S?o Paulo at Ribeir?o Preto, Ribeir?o Preto, Brazil
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Abstract: | There is considerable evidence that drug-paired cues become associated with drug effects. It has been hypothesized that these
cues act as Pavlovian conditional stimuli (CSs), and elicit conditional compensatory responses that contribute to tolerance.
On the basis of a conditioning analysis of tolerance, we would expect that is should be possible to establish drug-paired
cues as occasion setters, as well as conditional stimuli. Using feature-positive discrimination training, we evaluated the
contribution of occasion-setting stimuli (as well as CSs) to tolerance to the hypothermic effect of ethanol in rats. The results
indicated that a complete associative analysis of drug tolerance should incorporate not only the CS properties of predrug
cues, but also the occasion-setting properties of such cues. The findings have implications for interpreting conflicting findings
concerning extinction of tolerance and for cue-exposure treatments of addiction. |
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