Childhood sexual abuse and impulsive personality traits: Mixed evidence for moderation by DRD4 genotype |
| |
| Affiliation: | 1. Geisinger-Bucknell Autism & Developmental Medicine Institute, Geisinger, 120 Hamm Drive, Suite 2A, Lewisburg, PA 17837, United States;2. Department of Population Health Sciences, Geisinger, Danville, PA, United States;3. Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States;4. Department of Imaging Science and Innovation, Center for Health Research, Geisinger, Danville, Pennsylvania, United States;5. Neuroscience Institute, Geisinger, Danville, Pennsylvania, United States;6. Department of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, United States;1. Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Melbourne, Australia;2. School of Psychology, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia;3. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia;4. Orygen, The National Centre of Excellence in Youth Mental Health, Victoria, Australia;5. Orygen, Centre for Youth Mental Health, The University of Melbourne, Victoria, Australia;6. Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands;7. Department of Psychiatry and Psychology, Hospital Clinic, IDIBAPS, CIBERSAM, Institute of Neuroscience, University of Barcelona, Barcelona, Spain;8. Department of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands;9. Department of Psychiatry, Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands;10. Arkin Mental Health Care, Amsterdam, The Netherlands;11. School of Psychological Sciences, Institute of Psychology, Health and Society, The University of Liverpool, Liverpool, UK |
| |
| Abstract: | This project examines associations between childhood sexual abuse (CSA) and two dimensions of impulsivity (sensation seeking and premeditation), and tests whether CSA-personality associations are moderated by the DRD4 exon III VNTR polymorphism. Sample 1 is from a longitudinal study of university students measured at 10 waves over ages 18–24 years (n = 500). Sample 2 is from a national sample of young adult sibling pairs, ages 18–24, from the National Longitudinal Study of Adolescent Health (n = 2559). In both samples, CSA was associated with elevated sensation seeking. In Sample 1, the association between CSA and sensation seeking was moderated by DRD4 genotype; this gene × environment interaction effect, however, was not replicated in Sample 2. Results suggest new avenues for research on CSA in the area of normal-range personality variation. |
| |
| Keywords: | Sensation seeking Impulsivity Childhood sexual abuse Gene-environment interaction Diathesis stress Differential susceptibility |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
