| 通过打破抗原特异性T细胞免疫耐受控制慢性HBV感染 |
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| 引用本文： | 刘占举,闫剑婷.通过打破抗原特异性T细胞免疫耐受控制慢性HBV感染[J].医学与哲学,2005(10). |
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| 作者姓名： | 刘占举 闫剑婷 |
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| 作者单位： | 郑州大学第二附属医院消化内科、郑州大学消化疾病研究所 河南郑州 450014
(刘占举)，湖南省建筑工程学校医院 河南郑州 450007(闫剑婷) |
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| 摘 要： | 乙型肝炎病毒(HBV)感染诱导机体抗病毒免疫应答,若不能对病毒有效清除,体内抗原特异的CTL降低,出现抗原特异性T细胞免疫耐受,造成慢性肝脏炎症。分析HBV感染时抗原特异性T细胞免疫耐受机制,并通过打破免疫耐受预防HBV感染。
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| 关 键 词： | 乙型肝炎病毒 细胞毒杀伤细胞 免疫耐受 肝炎 |
Prevention of Hepatitis B Infection through Breaking Antigen-specific T Cell Tolerance |
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| LIU Zhan-ju.Prevention of Hepatitis B Infection through Breaking Antigen-specific T Cell Tolerance[J].Medicine & Philosophy:Humanistic & Social Medicine Edition,2005(10). |
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| Authors: | LIU Zhan-ju |
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| Institution: | LIU Zhan-ju.Department of Gastroenterology,The Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China |
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| Abstract: | Hepatitis B virus(HBV) infection causes anti-virus immune response.If HBV is not eradicated after infection,antigen-specific CD8~ T cells(CTL) are decreased,and antigen-specific T cell tolerance is present,leading to chronic hepatocellular damage.This paper analyzed the mechanism of antigen-specific T cell tolerance during HBV infection in order to prevent HBV infection via breaking immune tolerance. |
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| Keywords: | hepatitis B virus cytotoxic T cell immune tolerance hepatitis |
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