| 解偶联蛋白2基因启动子-866G／A多态性与2型糖尿病的相关性研究 |
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| 引用本文： | 刘琳,关玉峰,李政,孙崴,张霞,张萍,苏本利. 解偶联蛋白2基因启动子-866G／A多态性与2型糖尿病的相关性研究[J]. 医学与哲学(人文社会医学版), 2009, 30(3): 50-52 |
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| 作者姓名： | 刘琳 关玉峰 李政 孙崴 张霞 张萍 苏本利 |
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| 作者单位： | [1]大连医科大学附属第二医院内分泌科,辽宁大连116027 [2]普兰店市中心医院泌尿内科,辽宁普兰店116200 |
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| 摘 要： | 研究解偶联蛋白-2基因启动子常见-866G／A基因多态性（UCP2—866G／A）与2型糖尿病发病相关性。用多聚酶链反应-限制内切酶长度多态性技术检测了76例非糖尿病对照（NDM）和115例糖尿病患者（DM）的UCP2—866G／A基因型分布，并分析各基因型与胰岛功能、代谢参数的差异性。结果DM的AA基因型分布显著高于NDM（32．2％vs15．8％，χ^2=6．526，P〈0．038）。在NDM组GG型携带者空腹C肽（FCP）水平高于AA和GG组（两两比较分别为t=2．99，P=0．005和t=2．229，P=0．03）；在DM各基因型之间FCP和餐后2小时C肽（2hCP）情况与NDM对照相似，各基因型混和餐刺激后2hCP差异更加明显。结论为UCP2—866G／A基因多态性与大连地区2型糖尿病发病相关，该基因多态性主要影响胰岛β细胞分泌功能。
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| 关 键 词： | 糖尿病 解偶联蛋白2 基因多态性／遗传学 |
UCP-2 Gene Promoter -866G/A Polymorphism Related to the Development of Type 2 Diabetes Mellitus in Chinese |
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| Affiliation: | LIU Lin, GUAN Yu- feng, Li Zheng , et al. (The Secondary Affiliated Hospital of Dalian Medical University, Dalian 116027, China) |
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| Abstract: | This study is to investigate the association of uncoupled protein 2 gene promoter -866G/A polymorphism （UCP2 -866G/A） with the development of type 2 diabetes mellitus. UCP2 -866G/A was determined with polymerase chain reaction-restriction fragment long polymorphism in 115 diabetic （DM） and 76 non-diabetic subjects （NDM）. The frequency of AA genotype in DM than in NDM （32.2% vs. 15.8%,χ^2 =6. 526,P〈0. 038）. In NDM C- peptide levels with AA and GG genotypes were lower than that with GA genotype （compared with GA t= 2.99, P= 0. 005 and t= 2. 229, P=0.03 respectively）. The trends of C-peptide levels （fasting and 2 hour postprandial） in different genotypes of DM were similar to NDM, but the differences were only statically for 2 hour postprandial C-peptide levels. Conclusion The UCP2 -866G/A is related to the development of type 2 diabetes mellitus through its effect on insulin secretion. |
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| Keywords: | diabetes mellitus uncoupling protein 2 polymorphism/genetics |
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