Effects of systemic glucose injection on the development of amygdala kindling in rats. |
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| Authors: | M R Priel Z A Bortolotto E A Cavalheiro |
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| Institution: | Laboratório de Neurologia Experimental, Escola Paulista de Medicina, S?o Paulo, Brasil. |
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| Abstract: | The effects of systemic glucose administration on the development of electric amygdaloid kindling seizures were examined in Wistar rats. Daily intraperitoneal injections of glucose 100 mg/kg, 20 min prior to each amygdaloid stimulation did affect the rate of kindling development in comparison with the saline-injected group. The number of stimulations required to reach stage 5 was lower in animals treated with glucose. The facilitation of kindling development found in glucose-treated rats is related to a specific decrease in the number of stimulations needed to evolve from stage 2 to stage 3. These results indicate that systemic glucose administration facilitates amygdaloid kindling in rats. |
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