要注意中药对肝的损伤作用

含有生物碱类、皂苷类、萜类、毒蛋白类、重金属类成分的中药易致急性肝损伤.中药对肝脏损伤的原因及机制较为复杂,可能与药物对肝脏的直接毒性或特异性体质有关.此外,中药炮制方法、给药途径、剂型、剂量、疗程及配伍不当也会引起药物性肝损伤.中药所致的药物性肝损伤的诊断主要依据用药史、发病的时间、过程和临床表现并排除其他因素.治疗可选用还原型谷胱甘肽、S-腺苷蛋氨酸、多烯磷脂酰胆碱、熊去氧胆酸、水飞蓟素等药物,重症可选择人工肝脏支持治疗.

Pay Attention to the Role of Traditional Chinese Medicine on Liver Injury

Traditional Chinese medicine containing alkaloids, saponins, terpenoids, toxic proteins and heavy metal compound （s） are prone to cause acute liver injury. Herbs on the causes and mechanisms of liver injury is more complex, and may be related to direct toxic drugs on the liver or specific physique. In addition, the way of traditional Chinese medicine processing methods, route of administration, formulation, dosage, duration and improper compatibility can also cause drug-induced liver injury. The diagnosis of drug-induced liver injury caused by traditional Chinese medicine is mainly based on medical history, onset time, process, clinical manifestations and the exclusion of other factors. Glutathione, S-adenosylmethionine, polyene phosphatidylcholine, ursodeoxycholic acid, silymarin and other drugs can be used as therapies, and artificial liver support therapy for severe cases.