Metabolic control and auditory information processing at altered glucose levels in insulin-dependent diabetes |
| |
| Authors: | C S Holmes |
| |
| Affiliation: | 1. Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China;2. Affiliated Hospital of Taishan Medical University, Taian, Shandong Province, China;3. Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China;4. Department of Endocrinology, Jinan Central Hospital, Jinan, China;1. Center for Health Technology and Services Research (CINTESIS), Department of Education and Psychology, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal;2. ISPA – Instituto Universitário, William James Center for Research, Rua Jardim do Tabaco 34, 1149-041 Lisboa, Portugal;3. Centre for Psychology at University of Porto, Faculty of Psychology and Education Sciences, University of Porto, Rua Alfredo Allen, 4200–135 Porto, Portugal;4. Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal;5. School of Psychology and Neuroscience, University of St Andrews, St Mary''s Quad, South Street, St Andrews, Fife, KY16 9JP, Scotland, United Kingdom;1. Institute of Energy Efficiency and Sustainable Building E3D, RWTH Aachen University, Aachen, Germany;2. Computer Graphics Group, RWTH Aachen University, Aachen, Germany;3. Civil and Environmental Engineering, Stanford University, CA 94305, USA;4. School of Mech. & Materials Eng., ERC and UCD Energy Institute, UCD, Dublin, Ireland;1. Department of Architecture and Civil Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, China;2. School of Design, Hunan University, Changsha, Hunan, 410082, China |
| |
| Abstract: | Previous work with a visual reaction time (RT) paradigm showed rate of mental processing to be slowed during a state of brain energy depletion (i.e., hypoglycemia). The present study employed an analog auditory RT paradigm to determine if modality differences in processing information might occur in response to glucose alteration. A balanced crossover design was used in which men with insulin-dependent diabetes completed RT tasks of increasing complexity at each of the following glucose levels: hypoglycemia (60 mg/dL), normoglycemia/control (110 mg/dL), and hyperglycemia (300 mg/dL). Results revealed two performance groups. A convergent group displayed slower RT responding during hypoglycemia, consistent with the visual RT pattern of results. A divergent group displayed better responding on one RT measure during hypoglycemia, and generally poorer responding on all RT measures during the other glucose conditions. Subjects in the divergent group maintained more stringent metabolic control and tended to have experienced more episodes of hypoglycemic unconsciousness. The present results provide the first evidence that more stringent metabolic control may be related to generally slower rates of processing auditory information. Possible explanations for these findings include hypotheses of immutable structual derangement, state-dependent performance effects, and a U-shaped response curve. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
