伴家族史的2型糖尿病危险因素的病例对照研究

为探讨2型糖尿病代谢特征及发病的危险因素，选取大连地区91例有家族史的T2DM患者为病例组，以44例患者的配偶（糖耐量正常）为对照组，进行流行病学问卷调查和体格检查，同时测定空腹血糖、空腹胰岛素、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白等指标，采用稳态模型法计算两组的胰岛素抵抗指数和β细胞功能指数，并进行多因素非条件Logistic回归分析。结果显示：TG、腰臀比和Ln（HOMAIR）病例组高于对照组，而Ln（HOMAβ）则病例组低于对照组，均具有统计学意义（P〈0．05）。多因素非条件Logistic回归分析结果提示，影响T2DM发病的因素有心血管疾病史、Ln（HOMAIR）及Ln（HOMAβ）。由此可见T2DM患者存在血脂代谢异常；心血管疾病史和Ln（HOMAIR）为发病的危险因素，Ln（HOMAβ）为保护因素。

A Case Control Study on Risk Factors of Type 2 Diabetes With Family History

To investigate the metabolism character and risk factors of type 2 diabetes mellitus （T2DM）, we select 91 T2DM who had family history and 44 non- diabetic spouses as controls in Dalian. A questionnaire survey and medical examination were conducted. The fasting plasma glucose （FPG）, fasting insulin （FINS）, total cholesterol （TC）, total triglyeeride （TG） , high- density lipoprotein （HDL） , low-density lipoprotein （LDL） were measured. Insulin resistance index （ HOMA IR） and β-cell function index （HOMAβ） were calculated, and multivariate logistic regression analysis was performed. As a result TG, waist hip ratio （WHR） and Ln（HOMAIR） were higher in T2DM than those in control , but Ln （HOMAβ） were lower than control（P（0.05）. The results of multivariate logistic analysis showed that cardiovascular disease history, Ln（HOMAIR） and Ln（HOMAβ） influenced the incidence of T2DM. We can draw a conclusion that T2DM patients appeare dyslipidaemia; cardiovascular disease history and Ln（HOMAIR） are risk factors, and Ln（HOMAβ） is a protective factor.