Lateralized effects of subthalamic nucleus stimulation on different aspects of speech in Parkinson's disease |
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Authors: | Santens Patrick De Letter Miet Van Borsel John De Reuck Jacques Caemaert Jacques |
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Institution: | Department of Neurology, Ghent University Hospital, Belgium. patrick.santens@rug.ac.be |
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Abstract: | In this report, we have analyzed the effects of left and right STN stimulation separately on different aspects of speech. Significant differences were found between left and right stimulation. It appears that selective left-sided stimulation has a profoundly negative effect on prosody, articulation and hence intelligibility. Right-sided stimulation does not display this side-effect. There is no significant difference in speech characteristics between bilateral stimulation on and off. We suggest that a balanced tuning of bilateral basal ganglia networks is necessary for speech, and that the left circuit is probably dominant. |
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