细菌感染性疾病中的对立统一规律与Quorum Sensing系统

引起人类细菌性感染的病原菌可以分为条件致病菌和非条件致病菌,不同性质的细菌引起的感染决定了感染矛盾的特殊性,对于不同质的矛盾,只有用不同质的方法才能解决。抗生素的发明和使用为人类控制感染性疾病的同时,这种单纯的“对抗”的解决方法也引出了一些新的矛盾。因此,细菌感染矛盾的特殊性决定我们不能采用千篇一律的“对抗斗争”形式,而必须寻求一种特殊的解决方式。对QS系统的研究发现在细菌表现致病性过程中发挥重要作用,通过QS系统减弱细菌的致病性而不杀死细菌的“抗致病性药物”来治疗感染成为一种新的抗感染思路,这种“抗致病性”概念使我们抗感染的态度从与细菌“对抗”转变为“共生”,因而QS系统可以为这种特殊矛盾提供一个合理的解决方式。

The Law of the Unity of Opposites in Bacterial Diseases and Quorum Sensing System

The bacteria that cause diseases include opportunistic pathogen and non-opportunistic pathogen. The invention and usage of antibiotics have helped in preventing against various diseases, however, this "antagonism" solution without differention has drawback of drug-resistance. Thus, it's necessary to develop another strategy, rather than "antagonism", to treat these diseases.The approach of research in quorum sensing (QS) offers us an option to treat bacterial infection on the principle of "anti-pathogenic drug" without killing them. The principle of "anti-pathogenic" would change clinic thought from "antagonism" to "commensalism", therefore it's reasonable to resolve this contradiction through QS system.