| 自由基在神经外科手术时脑保护中的意义 |
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| 引用本文： | 周强. 自由基在神经外科手术时脑保护中的意义[J]. 医学与哲学(人文社会医学版), 2007, 28(4): 13-15 |
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| 作者姓名： | 周强 |
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| 作者单位： | 上海交通大学医学院苏州九龙医院神经外科 江苏苏州215021 |
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| 摘 要： | 神经外科手术中脑内自由基(主要是氧自由基)产生增加,脂质过氧化反应增强,造成细胞结构和功能上的继发性损伤。自由基在继发性损伤中的具体机制尚未完全清楚,可能与缺血级联反应、缺血再灌注和细胞凋亡有关。术中采取措施清除自由基以及减少自由基的产生将有助于保护损伤的脑组织。
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| 关 键 词： | 自由基 脑保护 神经外科 手术 |
| 文章编号： | 1002-0772（2007）04-0013-03 |
| 修稿时间： | 2007-04-032007-04-14 |
Significance of Free Radicals in Intraoperative Brain Protection during Neurosurgery |
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| ZHOU Qiang.. Significance of Free Radicals in Intraoperative Brain Protection during Neurosurgery[J]. Medicine & Philosophy:Humanistic & Social Medicine Edition, 2007, 28(4): 13-15 |
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| Authors: | ZHOU Qiang. |
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| Affiliation: | Department of Neurosurgery , Suzhou Kowloon Hospiptal , Shanghai Jiao Tong University School of Medicine, Suzhou 215021, China |
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| Abstract: | Free radicals, mainly oxygen-derived, increases in brain during neurosurgery, along with lipid peroxidation reaction upgraded ,which may lead to the secondary brain damage of the cerebral cell in the structure and function. The mechanisms contributing to the brain damage have not yet been well clarified. The mechanisms may be related with ischemic cascade reaction, ischemic reperfusion and cell apoptosis. The steps to remove or reduce the production of free radicals during operation may be helpful to protect the damaged cerebral cells. |
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| Keywords: | free radical brain protection neurosurgery operation |
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